Ipamorelin is an intriguing new discovery in muscle building that is gaining significant attention in the bodybuilding community. Similar to the GHRP-6 peptide (growth hormone releasing hexapeptide), it is a synthetic peptide with potent Growth Hormone releasing capabilities. These GH releasing characteristics are particularly appealing to athletes and bodybuilders, as they can greatly influence the extent of muscle growth and the rate of fat burning.
Athletes typically use Ipamorelin at dosages of 200 mcg to 300 mcg, administered two or three times a day with a small insulin needle for injection. They often begin with a lower dose due to potential side effects, which may include headaches or sensations akin to a head-rush. Ipamorelin can be taken at any time, but it is considered optimal to use it about 30-45 minutes prior to workouts, as this timing maximizes the pulse of Growth Hormone (GH) produced, facilitating better growth.
Research on Ipamorelin's effects on bone growth, body weight, and GH release has yielded some noteworthy results.
In one study, varied doses were administered over 15 days to observe the group’s responses.
Results indicated a clear and dose-dependent impact on body weight gain, but the treatment group did not exhibit changes in total IGF-I levels. Additionally, there were no serum indicators of bone development observed; for instance, the quantity of cells in the broad section of the tibia (shinbone) remained largely unchanged. This is positive as it implies muscle growth without an increased risk of bone or cartilage deformities.
The pituitary's reaction to a high intravenous dose of Ipamorelin revealed that plasma GH levels were significantly decreased, while comparable doses of GHRH showed no change. This is encouraging as it suggests that Ipamorelin might not suppress the body’s natural GH production, reinforcing the idea that Ipamorelin acts as a selective GH releaser.